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Product Description
Andrographolide appears as a white to off-white crystalline powder with a melting point of approximately 230–234 °C. It is poorly soluble in water but exhibits better solubility in ethanol, DMSO, and alkaline solutions, a characteristic that influences its formulation in skincare products. Its molecular structure, featuring a labdane skeleton with a γ-lactone ring, enables interaction with key enzymes and receptors involved in inflammation and cell proliferation. Micronization or nanoencapsulation techniques are often used to improve its dispersion in aqueous bases.
Attributes
|
English Name |
Andrographolide |
| CAS NO | 5508-58-7 |
| Molecular Formula | C₂₀H₃₀O₅ |
| Molecular Weight | 350.45 g/mol |
| Appearance | White to off-white crystalline powder |
| Melting Point | 230–234 °C |
| Density | Approximately 1.2 g/cm³ |
| Solubility | Sparingly soluble in water; soluble in ethanol, DMSO |
| Stability | Stable under cool, dry conditions; sensitive to heat and acidic pH |
Antibacterial Activity
Andrographolide exhibits broad-spectrum antibacterial effects, particularly against Propionibacterium acnes and Staphylococcus aureus. It works by inhibiting bacterial quorum sensing and disrupting biofilm formation, reducing microbial colonization in hair follicles. This action helps clear acne lesions and prevent recurrence, with studies showing significant reduction in bacterial counts after 4–6 weeks of topical use. Unlike antibiotics, it does not promote microbial resistance, making it a sustainable choice for acne management.
Anti-Inflammatory Effects
As a potent inhibitor of NF-κB and MAPK signaling pathways, andrographolide reduces the production of pro-inflammatory cytokines (TNF-α, IL-6) and chemokines. It scavenges reactive oxygen species (ROS) and inhibits neutrophil migration, alleviating redness, swelling, and irritation in conditions like acne, rosacea, and contact dermatitis. Clinical trials have shown it to be as effective as 1% hydrocortisone in reducing inflammatory symptoms without steroid-related side effects.
Keratolytic and Sebum-Regulating Properties
Andrographolide regulates keratinocyte proliferation and differentiation, preventing abnormal keratinization that leads to comedone formation. It also inhibits 5α-reductase activity, reducing sebum production and pore congestion. This dual action makes it suitable for oily, acne-prone skin, as it unclogs pores and balances sebum secretion without over-drying the skin.
Antioxidant and Anti-Aging Effects
By neutralizing free radicals, andrographolide protects skin from oxidative damage, a major driver of photoaging. It stimulates collagen synthesis by activating TGF-β signaling and inhibits matrix metalloproteinases (MMPs), reducing the appearance of fine lines and improving skin elasticity. Topical application has been shown to enhance skin barrier function and reduce UV-induced pigmentation.
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Acne Treatments
Andrographolide is incorporated into 2–5% creams, gels, and serums for mild to moderate acne. Brands like The Ordinary offer formulations combining andrographolide with niacinamide to target bacteria, inflammation, and hyperpigmentation.
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Soothing Formulations
For sensitive or irritated skin, masks and lotions with 1–3% andrographolide calm redness and inflammation, often paired with aloe vera or centella asiatica.
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Anti-Aging Serums
Products designed for mature skin use andrographolide to boost collagen and reduce oxidative stress, sometimes in combination with retinol or vitamin C.
Research and Innovation
Our commitment to excellence extends beyond production. We invest in ongoing research and development to stay at the forefront of ergothioneine science. This ensures that our products are based on the latest findings and are continuously improved for maximum effectiveness.
Sustainability and Ethics
At Shaanxi Bieyouth Biotech Co.,Ltd. we are committed to sustainable and ethical practices. We source our raw materials responsibly and ensure that our production processes have a minimal environmental impact. Our dedication to ethical standards is reflected in every aspect of our business, from our supply chain to our customer relationships.
Customer Trust
We understand that trust is earned. That's why we prioritize transparency and communication with our customers. We provide detailed information about our products, their benefits, and the science behind them. Our goal is to empower our customers to make informed decisions about their health and well-being.
Global Reach
Ergothioneine's benefits are universal, and so is our reach. We distribute our products worldwide, making this elite antioxidant accessible to health-conscious individuals across the globe. Our international presence allows us to serve a diverse range of customers and contribute to global health.
The Future of Health
As we continue to explore the potential of ergothioneine, we are excited about the future of health and wellness. We believe that by offering high-quality ergothioneine supplements, we are contributing to a healthier, more vibrant world. Join us in this journey towards optimal health and discover the difference ergothioneine can make in your life.
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About Us
Shaanxi Bieyouth Biotech Co., Ltd. is proud to offer Andrographolide, a cutting-edge supplement for those seeking to enhance their cellular health and protect against the ravages of time. By incorporating our Andrographolide into your health regimen, you are taking a proactive step towards safeguarding your body's cells and promoting a longer, healthier life. Experience the power of this elite antioxidant and embrace the benefits of Andrographolide for your well-being.
