Leuprolide acetate is a synthetic, long-acting gonadotropin-releasing hormone (GnRH) agonist with high affinity for pituitary GnRH receptors. Its mechanism of action is dose- and time-dependent:
Product Description
Leuprolide acetate a GMP-compliant GnRH agonist, is produced under strict quality standards with DMF documentation for regulatory approval. This peptide-based compound (≥98% purity) modulates hormone release, packaged as a white powder in sealed vials. Stored at -20°C, it is ideal for endocrinology and oncology research. Intended for R&D use, ensuring adherence to FDA guidelines.
Attributes
| English Name | Leuprolide acetate | Density | / |
| CAS NO | 74381-53-6 | Index of Refraction | / |
| Molecular Formula | C61H88N16O14 | Storage Condition | -20°C |
| Mol. wt. | 1269.47 | Solubility | MSO (Slightly), Methanol (Slightly) |
| EINECS No. | 686-285-8 | Form | Powder |
| MDL No. | MFCD00072080 | Colour | White to Off-White |
| Melting Points | 150-155°C | PH Value | |
| Stability | Stable, but air-sensitive and very hygroscopic - store under argon. Incompatible with acids, acid chlorides, acid anhydrides, oxidizing agents. | ||
Mechanism of Action
Initial Stimulation: Short-term activation of pituitary GnRH receptors, causing a transient surge in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion.
Subsequent Suppression: Chronic administration desensitizes pituitary receptors, reducing LH/FSH production. This leads to decreased gonadal steroidogenesis (testosterone in males, estrogen/progesterone in females), effectively "medical castration" for therapeutic purposes.
Leuprolide acetate (GMP DMF) effectively treats prostate cancer by reducing testosterone levels, slowing tumor growth, and alleviating symptoms like pain and urinary obstruction.
It helps manage endometriosis by suppressing ovarian hormone production, relieving pelvic pain and reducing lesion size.
In pediatric patients, it delays puberty progression in central precocious puberty, allowing for more appropriate development.
Its GMP-certified quality ensures safety and efficacy in hormone-related conditions, supporting reliable clinical outcomes.
Central Precocious Puberty (CPP)
Assisted Reproductive Technology (ART)

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