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Colostrum Basic Protein (CBP): The Bone-Targeting Bioactive Protein for Osteoblast Activation, Bone Density Enhancement, and Skeletal Vitality
Amino Acids, Proteins and Peptides

Colostrum Basic Protein (CBP): The Bone-Targeting Bioactive Protein for Osteoblast Activation, Bone Density Enhancement, and Skeletal Vitality

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Colostrum Basic Protein (CBP), also known as Concentrated Whey Active Protein or Colostrum Growth Protein, is a class of low-molecular-weight bioactive proteins extracted from bovine colostrum, with a molecular weight range of 1–30 kDa. CBP is not a single protein but a collective term for the growth factor-rich fraction of bovine colostrum, encompassing transforming growth factor (TGF), insulin-like growth factor (IGF-1), epidermal growth factor (EGF), and other bioactive peptides. It acts directly on bone cells to coordinate the dynamic balance between osteoblasts (bone-forming cells) and osteoclasts (bone-resorbing cells), thereby promoting bone growth, enhancing bone density, and supporting skeletal health. Its extremely low natural abundance—approximately 0.04% of bovine colostrum—makes it a highly concentrated and valuable functional ingredient.

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    Product Description

    Our Colostrum Basic Protein is a premium-grade, standardized bioactive protein produced from fresh bovine colostrum sourced from healthy, pasture-raised dairy herds in New Zealand or equivalent certified regions. The manufacturing process involves a series of gentle, non-denaturing steps: sterilization, defatting, centrifugal separation to remove casein, α-lactalbumin, and β-lactoglobulin, followed by microfiltration, ultrafiltration, and freeze-drying to yield a fine, free-flowing powder. The product appears as a Light yellow powder with a characteristic mild dairy odor and excellent water solubility. It is standardized to contain ≥80% protein, with ≥50% of the protein content falling within the 1–30 kDa molecular weight range. CBP was approved as a New Resource Food by the Ministry of Health of China in 2009, with a recommended daily intake of ≤100 mg. It is ideal for formulating growing-up milk powders, bone health supplements, functional beverages, and dairy products targeting skeletal development and bone density maintenance.
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    Attributes

    English Name Colostrum Basic Protein (CBP) Density /
    CAS NO 42971-09-5 Index of Refraction /
    Molecular Formula / (Mixture of bioactive proteins; no unified formula) Storage Condition Cool Dry Area (sealed, below 25°C, away from light and moisture)
    Mol. wt. 1–30 kDa (primary active fraction) Solubility Soluble in water
    EINECS No. / Form powder
    MDL No. / Colour Light yellow
    Melting Points / PH Value /
    Stability Good stability under normal temperature, dry, light-proof and sealed conditions. Retains bioactivity after heat treatment and digestive enzyme exposure.
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    Nutritional Composition

    Colostrum Basic Protein is a concentrated bioactive protein fraction derived from bovine colostrum. Its typical composition includes: Protein content: ≥80% 1–30 kDa molecular weight fraction: ≥50% of total protein Bioactive growth factors: Transforming growth factor (TGF), insulin-like growth factor-1 (IGF-1), epidermal growth factor (EGF), and other growth factors naturally present in bovine colostrum Moisture: ≤7% Ash: ≤3% It contains no added preservatives, artificial colors, or synthetic hormones. CBP is a protein, not a hormone, and does not contain exogenous steroid hormones.

    Health Benefits

    Colostrum Basic Protein (CBP)'s health benefits are multifaceted, making it a valuable addition to any health regimen:

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    Enhances Bone Density and Bone Strength
    Animal studies on juvenile Sprague-Dawley rats showed that CBP supplementation at 0.5% and 5% of diet for 7 weeks significantly increased femur length and weight, with the high-dose group showing significantly higher bone density and body weight compared to controls. Critically, the bone growth promoted by CBP did not come at the expense of bone strength.
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    Coordinates Bone Remodeling Balance
    CBP maintains the dynamic equilibrium between osteoclasts and osteoblasts by inhibiting osteoclast activity while promoting osteoblast proliferation and activity. This coordinated action supports healthy bone metabolism, helps prevent bone loss associated with long-term low-calcium intake, and is beneficial for preventing osteoporosis.
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    Elevates Growth-Related Biomarkers
    CBP supplementation has been shown to significantly increase serum levels of growth hormone (GH), insulin-like growth factor-1 (IGF-1), and osteocalcin—a specific marker of bone formation and turnover. These biomarkers are closely associated with bone growth and skeletal development.
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    Supports Cognitive Function (Emerging Evidence)
    Preliminary studies using zebrafish models suggest that CBP may inhibit acetylcholinesterase activity and increase dopaminergic neuron area, indicating potential benefits for improving memory and cognitive function. These findings warrant further clinical investigation.

    Applications

    Colostrum Basic Protein (CBP) is suitable for a variety of health-conscious individuals:
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    Growing-Up Milk Powders & Children's Nutrition
    Incorporated into growing-up formula milk powders at 20–100 mg per 100 g to support skeletal development and calcium absorption during growth years. CBP is excluded from infant formulas for children under 1 year of age.
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    Bone Health Supplements
    Formulated into capsules, tablets, and powdered supplements targeting bone density maintenance for adolescents, perimenopausal women, and the elderly. Often combined with calcium, vitamin D, and vitamin K for synergistic bone support.
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    Functional Dairy & Beverages
    Added to high-calcium milk, yogurt, and functional beverages to enhance bone-nutritional value and support calcium bioavailability. Typical addition level: 0.05%–0.5% of total mass.

    Additional Information

    Research and Innovation
    Our commitment to excellence extends beyond production. We invest in ongoing research and development to stay at the forefront of Colostrum Basic Protein (CBP) science. This ensures that our products are based on the latest findings and are continuously improved for maximum effectiveness.
    Sustainability and Ethics
    At Shaanxi Bieyouth Biotech Co.,Ltd. we are committed to sustainable and ethical practices. We source our raw materials responsibly and ensure that our production processes have a minimal environmental impact. Our dedication to ethical standards is reflected in every aspect of our business, from our supply chain to our customer relationships.
    Customer Trust
    We understand that trust is earned. That's why we prioritize transparency and communication with our customers. We provide detailed information about our products, their benefits, and the science behind them. Our goal is to empower our customers to make informed decisions about their health and well-being.
    Global Reach
    Colostrum Basic Protein (CBP)'s benefits are universal, and so is our reach. We distribute our products worldwide, making this elite antioxidant accessible to health-conscious individuals across the globe. Our international presence allows us to serve a diverse range of customers and contribute to global health.
    The Future of Health
    As we continue to explore the potential of Colostrum Basic Protein (CBP), we are excited about the future of health and wellness. We believe that by offering high-quality Colostrum Basic Protein (CBP) supplements, we are contributing to a healthier, more vibrant world. Join us in this journey towards optimal health and discover the difference Colostrum Basic Protein (CBP) can make in your life.

    Quality Assurance

    We uphold strict quality control standards to ensure that our Colostrum Basic Protein (CBP) meet the highest standards of purity and efficacy. Each batch is rigorously tested to confirm the presence of the active compound and to screen for potential contaminants.

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    About Us

    Shaanxi Bieyouth Biotech Co., Ltd. is proud to offer Colostrum Basic Protein (CBP), a cutting-edge supplement for those seeking to enhance their cellular health and protect against the ravages of time. By incorporating our Colostrum Basic Protein (CBP) into your health regimen, you are taking a proactive step towards safeguarding your body's cells and promoting a longer, healthier life. Experience the power of this elite antioxidant and embrace the benefits of Colostrum Basic Protein (CBP) for your well-being.
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